GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs9782955 | 1 | rs4659612 | chr1:236033290 | LYST | chr1:235824345-236046940:- | -0.3 | -9.57 | 5.62E-20 | Systemic lupus erythematosus |
| THCA | cis | rs9782955 | 1 | rs4659613 | chr1:236033329 | LYST | chr1:235824345-236046940:- | 0.31 | 9.27 | 6.18E-19 | Systemic lupus erythematosus |
| THCA | cis | rs465969 | 1 | rs465969 | chr6:111655530 | KIAA1919 | chr6:111580482-111590259:+ | 0.4 | 5.53 | 5.16E-8 | Psoriasis |
| THCA | cis | rs9782955 | 1 | rs4660116 | chr1:236028841 | LYST | chr1:235824345-236046940:- | -0.32 | -9.66 | 2.78E-20 | Systemic lupus erythematosus |
| THCA | cis | rs9782955 | 1 | rs4660117 | chr1:236031533 | LYST | chr1:235824345-236046940:- | -0.31 | -9.89 | 4.2E-21 | Systemic lupus erythematosus |
| THCA | cis | rs4660808 | 1 | rs4660303 | chr1:40060473 | PABPC4 | chr1:40026485-40042521:- | -0.28 | -4.91 | 1.23E-6 | C-reactive protein levels or triglyceride levels (pleiotropy) |
| THCA | cis | rs4660306 | 1 | rs4660306 | chr1:45978675 | AKR1A1 | chr1:46016498-46035720:+ | 0.14 | 3.79 | 0.000169 | Homocysteine levels |
| THCA | cis | rs4660306 | 1 | rs4660306 | chr1:45978675 | CCDC163P | chr1:45960581-45965646:- | 1.1 | 31.61 | 3.27E-119 | Homocysteine levels |
| THCA | cis | rs4660306 | 1 | rs4660306 | chr1:45978675 | MUTYH | chr1:45794915-45806142:- | -0.21 | -5.11 | 4.55E-7 | Homocysteine levels |
| THCA | cis | rs4660306 | 1 | rs4660306 | chr1:45978675 | PRDX1 | chr1:45976708-45987609:- | 0.4 | 10.31 | 1.26E-22 | Homocysteine levels |
| THCA | cis | rs2275426 | 1 | rs4660317 | chr1:46326226 | CCDC163P | chr1:45960581-45965646:- | -0.51 | -10.1 | 7.22E-22 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs4660317 | chr1:46326226 | GPBP1L1 | chr1:46092978-46152302:- | 0.16 | 4.05 | 5.93E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs4660317 | chr1:46326226 | MMACHC | chr1:45965856-45976737:+ | -0.2 | -4.4 | 1.34E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs4660317 | chr1:46326226 | MUTYH | chr1:45794915-45806142:- | 0.31 | 8.53 | 1.99E-16 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs4660319 | chr1:46341623 | CCDC163P | chr1:45960581-45965646:- | -0.51 | -10.06 | 9.97E-22 | Body mass index |